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Product works good however I am getting cramps in the back of my neck. May not be worth having problems urinating if the neck cramps prevent me from doing normal work.
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Two patients from the tamsulosin group experienced serious AEs: one patient had precordial pain related to the study drug; the other patient had a cardiac valve disorder and symptoms of myocardial infarction, which were considered unrelated to the study drug.

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The search used the following combined medical subject heading terms and keywords: calcium channel blockers, nifedipine; alpha antagonist, tamsulosin; medical therapy, facilitated therapy, expulsive therapy, adjunctive therapy, medical management; and LUS, lower ureteral calculi, distal ureteral stone, distal ureteral calculi.

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In a post hoc analysis, the mean change from baseline IPSS storage and voiding subscores was summarized by treatment group using the last observation carried forward approach.

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Post-void residual volume taken at final study visit (12 month) to assess efficacy of starting with combination treatment with Dutasteride for one year and Tamsulosin for 3 months with subsequent as needed use of Tamsulosin in providing superior symptomatic improvement to BPH patients.

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If prostate cancer is suspected or the PSA level begins to increase during therapy, the patient should be referred to a urologist.

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Hepatic Impairment: The effect of hepatic impairment on dutasteride and tamsulosin pharmacokinetics has not been studied using JALYN.

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Finasteride inhibits the function of only one of the isoenzymes (type 2), whereas dutasteride inhibits both forms.

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The indices of progression are: worsening of symptoms (increase of three points in the IPSS); any deterioration of QoL score; acute urinary retention (AUR); recurrent urinary tract infection; urinary incontinence; formation of calcium deposits in the bladder; obstructive renal insufficiency; BPH-related surgery.

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In still another embodiment of the present invention, a fixed dose combination includes a dutasteride component and a tamsulosin component where the tamsulosin component includes a plurality of beads, wherein each bead includes a discrete layer that includes tamsulosin; and in a first portion of the plurality of beads, each bead further includes a pH independent layer and is devoid of a pH dependent layer.

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Diltiazem, a CYP3A4 inhibitor, may decrease the metabolism and clearance of Tamsulosin, a CYP3A4 substrate.

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